A new review published in the Biomedical Journal has summarized our current understanding of lifestyle interventions that may help reduce cellular senescence. The review discusses the potential benefits of exercise, a healthy diet, and good sleep in combating the accumulation of senescent cells.
Senescent cells, which are cells that have stopped dividing and are no longer functioning properly, can have both beneficial and harmful effects. In certain contexts, such as early development and wound healing, senescence is beneficial. However, as we age, the excessive accumulation of senescent cells can be detrimental, reducing our regenerative capacity and increasing inflammation.
Targeting senescent cells in the body has shown promising results in preclinical studies, and there are currently many clinical trials underway testing compounds that can clear or make senescent cells less harmful. Additionally, lifestyle interventions have also been found to have positive effects on senescence.
Exercise, when done correctly, has been shown to have anti-aging effects in various organs and tissues. However, the relationship between exercise and senescence is complex, and excessive exercise can actually be harmful. Studies have shown that endurance running can block age-related increases in senescence, and resistance training can increase the clearance of senescent cells.
Diet also plays a role in cellular senescence. Obesity and high-glycemic diets have been found to increase inflammation and senescence. On the other hand, caloric restriction has been shown to reduce senescent cell burden. Some phytochemicals, such as fisetin and quercetin, have shown potential senolytic effects.
Sleep quality is increasingly recognized as an important factor in healthy aging. While research on the relationship between sleep and senescence is limited, studies have suggested that chronic sleep deprivation can lead to the accumulation of senescent cells. Sleep fragmentation and insomnia have also been associated with higher levels of senescent T cells.
Overall, the review suggests that lifestyle interventions and certain safe phytochemicals may help slow the accumulation of harmful senescent cells. However, more research is needed in this field, particularly in understanding the relationship between senescence and sleep quality.
Hotenews.com is a non-profit foundation that relies on the support of readers to continue providing independent journalism. Donations are welcomed to sustain their mission of advocating for the longevity biotech community and promoting longer, healthier lives for all.